Our mission
Elkedonia is committed to introducing a pioneering, first-in-class antidepressant treatment with precision medicine.
Our ambition is to develop an innovative antidepressant treatment, that will be accessible to all patients, whatever their geographical location, age or comorbidities, fast-acting and free from risks of dependence, sedation or psychotic effects.
Our goal is to enable patients to rediscover the pleasures of life and significantly reduce the risks of suicide and relapse.
Our history
memory
of Elk-1 inhibition
on neuroplasticity
Elk-1 could act as
a therapeutic lever
a biotech start-up studio
antidepressants
This is Elkedonia
Elkedonia is focused on developing a safe, well-tolerated and effective therapy for depression, ensuring it is accessible to every patient in need.
We are pioneers
Elkedonia is leading a pioneering approach in antidepressant therapy. We are focusing on an innovative target, within neurons, in key brain circuits. Rather than acting at the synapse like all other antidepressants, our approach targets intracellular events and neuroplasticity, precisely targeting a highly selective signaling pathway.
Committed
A team of dedicated and unique people
Our values – Innovation, Commitment, Ambition and REsilience – come together to form our credo: ‘I CARE’, reflecting our desire to make a significant difference in patients’ lives.
Redefining relief with a breakthrough antidepressant for all patients
Evidence from both patient studies and preclinical research supports the role of our target in depression pathophysiology. Inhibiting its activity is expected to provide rapid and long-lasting relief for all patients. Our ambition is to act on key brain circuits to rewire resilience and bring patients new levels of relief.
Resilient
Learning and adapting to move forward
We see beyond challenges, identifying ways to turn them into opportunities. This approach is key in R&D for complex disorders, like mental health disorders. Driven by our passion to contribute to the bigger picture, we keep an open mind to advance innovation.
Ethics
Transparency, responsibility, and respect
We act with transparency, responsibility, and respect : Always and with everyone.
Follow our latest updates, breakthroughs and ideas on Elkedonia’s LinkedIn page.
Meet our team
We believe that great breakthroughs are born from the collaboration of passionate minds. Together, we transform biotechnological innovations into tangible solutions for tomorrow.

Delphine Charvin, PhD
Chief Executive Officer
Co-Founder & Board DirectorDelphine brings her entrepreneurial experience in biotech creation, fundraising and scale-up, alongside cross-functional expertise in drug discovery and clinical development within both startup and pharma environments. Delphine thrives on breaking boundaries, challenging conventions and reimagining possibilities. Her patient-first approach and dedication to fostering a purpose-driven team drives Elkedonia to deliver life-changing therapies.
Delphine Charvin, PhD

Founding Chief Executive Officer & Board Director
Delphine Charvin is an experienced drug developer, scientist and entrepreneur in neurological diseases. She brings two decades of experience from senior leadership and managerial positions in international pharmaceutical, biotech and start-up companies, including Addex Pharmaceuticals, Merck-Serono, Prexton Therapeutics, Lundbeck and Stalicla. As the Chief Scientific Officer of Prexton, she developed a program from lead identification up to clinical phase II and played a crucial role in the company development since inception, then series A and series B fundraising, and finally in the successful exit with the acquisition of the company by Lundbeck.
Prior to Elkedonia, Delphine was the Operating Partner of the startup studio Argobio. She has contributed to the set-up of a neurology franchise within the Studio and, together with Mélanie Rouillier, Yves Ribeill and Jocelyne Caboche, she developed the Elkedonia project from preincubation to NewCo creation. Delphine has 15 years of experience working with startups, biotechs, pharma companies and VCs. Over the past 10 years, she has held co-founding and managerial positions in drug discovery and clinical development companies that have raised over €150 million.
Delphine holds a PhD in Neuroscience from Paris VI Sorbonne University, France, a post-doctorate from Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland, and a Finance certification from INSEAD.

Mélanie Rouillier
VP, Chief Operations Officer & Co-Founder
Mélanie brings deep expertise in technology platforms, pharmacology, drug discovery and project management. She plays a key role in guiding Elkedonia’s strategic execution. Driven by a passion for making a tangible impact on patients' lives, she is committed to fostering operational excellence, and advancing innovation closer to patients.
Mélanie Rouillier

VP, Chief Operations Officer & Co-Founder
Mélanie Rouillier brings over 15 years of experience in project management and drug development in international and multi-cultural environments. She was previously Senior Project Coordinator at Medicines for Malaria Venture (MMV), where she managed more than 30 projects in a virtual public/private partnership setting, and then Scientific Project Manager at Argobio Studio. Prior to that, Mélanie was an Associate Scientist at Addex Therapeutics, where she gained expertise in in vitro pharmacology, HTS and drug discovery and development. Over the past 15 years, Mélanie has managed R&D activities ranging from target validation to IND filing for innovative small molecules targeting CNS and infectious diseases. She brings knowledge in technology platforms, in vitro pharmacology, high-thoughput screening, drug discovery, as well as strong communication and collaboration skills.
Mélanie holds an Engineer diploma, MSc in biotechnology from Ecole Supérieure de Biotechnologie de Strasbourg (ESBS), France, a Project Management Professional (PMP) Certification, and a Clinical Research Associate (CRA) degree.

Sarah Delbaere
Chief Financial Officer
Experienced Chief Financial Officer with 25+ years in the pharmaceutical sector, Sarah specializes in financial strategy, fundraising, IPOs, and change management. She supports biotech companies from start-up to growth, combining strategic vision with execution excellence, making her a key asset in dynamic, innovation-driven environments.
Sarah Delbaere
Chief Financial Officer
Sarah Delbaere is an accomplished Chief Financial Officer with over 25 years of leadership experience in the pharmaceutical and biotechnology sectors. She has consistently driven value creation by shaping financial strategy, securing major funding, and supporting the scaling of innovative healthcare companies.
A key partner to executive teams and investors, Sarah has led high-impact financial initiatives, including successful private and public fundraising, an IPO on Euronext, and strategic financing with institutional partners. She is deeply experienced in navigating complex environments, from start-up structuring to listed company governance.
Throughout her career, she has been a trusted contributor at Board level, presenting financial performance, strategic plans, and growth scenarios to directors and stakeholders, ensuring clear, data-driven decision-making.
Her track record includes senior leadership roles at Advicenne, Takeda France, and Ferring, where she drove transformation programs, optimised operations, and implemented best-in-class financial and governance frameworks. More recently, she has focused on supporting biotech ventures and incubators, bringing hands-on leadership across finance, funding, HR, and corporate structuring.
Sarah combines strategic vision with execution excellence, making her a key asset in dynamic, innovation-driven environments.
Sarah holds a University degree in Applied Economics, and a Licence in European Law from University of Ghent, Belgium.

Anna Quattropani, PhD
Chief Discovery Officer
Anna brings extensive expertise in drug discovery and early development, spanning medicinal chemistry, non-clinical development, CMC, and intellectual property. Driven by a passion for translating therapeutic hypotheses into medicines, she is committed to delivering new treatment options for patients.
Anna Quattropani, PhD
Chief Discovery Officer
Anna Quattropani is a seasoned biotech leader with over 25 years of expertise in medicinal chemistry, drug discovery, and non-clinical development. She has a proven track record in establishing drug discovery projects, designing small-molecule clinical candidates, and advancing them from discovery through Phase II clinical development.
Prior to joining Elkedonia, Anna held various roles at pharmaceutical companies (Serono, Merck KGaA) and biotech firms (Asceneuron, Draupnir Bio, Anavo Therapeutics). Her work spans a diverse range of drug targets and modalities, including targeted protein degradation, enzyme inhibition, orthosteric/allosteric GPCR and ion channel modulation, and protein-protein interaction modulation. She has contributed across multiple therapeutic areas, with a particular focus on neurological diseases. As a founding member of Asceneuron, she is inventor of ASN90, an O-GlcNAcase inhibitor licensed for Phase II development in progressive supranuclear palsy.
Anna earned her PhD in Organic and Organometallic Chemistry from the University of Geneva, Switzerland, and completed a postdoctorate at UC Irvine, USA. She is the inventor of 55 patents and the author of 23 peer-reviewed publications.

Francesca Houghton, PhD
In vitro Pharmacology Lead
Francesca brings expertise in protein science, biophysics and structural biology within the field of molecular neurobiology, driving in vitro pharmacology activities at Elkedonia. She plays a key role in integrating biochemical and biophysical data to guide drug discovery and optimisation. Motivated to translate molecular insights into clinical impact, she is committed to driving innovation for unmet medical needs.
Francesca Houghton, PhD

In vitro Pharmacology Lead
Francesca Houghton is an interdisciplinary scientist with a PhD in Molecular Neuroscience from the Francis Crick Institute and University College London (UCL). Her scientific background spans protein science, biophysics and structural biology, with a focus on characterising protein-ligand interactions and supporting drug discovery and optimisation.
She has worked on a range of molecular targets, from extracellular receptors to intracellular kinases, and brings hands-on expertise in advanced biophysical and structural techniques such as SPR, X-ray crystallography and cryo-EM. Her experience spans multiple modalities, from screening and characterising peptide inhibitors of protein-protein interactions to biophysical characterisation of small-molecule compounds.
Francesca thrives in fast-paced, collaborative environments and brings a track record of scientific communication, having presented at international conferences and led cross-disciplinary collaborations across academic and biotech settings.
Francesca holds a BA and MSc in Natural Sciences from the University of Cambridge, and a PhD in Molecular Neuroscience from the University College London (UCL).

Priscilla Van den Ackerveken, PhD
Translational Research Lead
Priscilla Van den Ackerveken, PhD

Delphine Gautier
Office Manager and Executive Team Assistant
Delphine is committed to contributing to a mission she truly believes in. Combining 12 years of experience in sales and management across diverse sectors with a Master's degree in Marketing and Intercultural Negotiation, she brings structure, care and a human touch to Elkedonia's daily operations.
Delphine Gautier
Office Manager and Executive Team Assistant
Delphine Gautier holds a Master’s degree in Marketing and Intercultural Negotiation and has built a 12-year career in sales coordination and management, working across industries including relocation services, insurance, and health-oriented products. Throughout her career, she has consistently been drawn to roles where her work carries a tangible impact, whether helping individuals through major life transitions or promoting solutions designed to improve daily wellbeing.
Before joining Elkedonia, Delphine crossed paths with Delphine Charvin and Mélanie Rouillier, where she was struck by their dedication, scientific vision, and unwavering commitment. When the opportunity arose to join their venture, it was a natural step, one that aligned perfectly with her core conviction that work should have meaning and serve a greater purpose.
At Elkedonia, she oversees the administrative and organizational backbone of the company, ensuring the organization runs smoothly across its international offices. From internal procedures and compliance to board logistics and team coordination, Delphine brings structure, care, and a human touch to Elkedonia’s daily operations.

Jocelyne Caboche, PhD
President of the Scientific Advisory Board & Co-Founder
Jocelyne Caboche is a world-renowned researcher specializing in intracellular signaling events involved in neuronal plasticity. She unraveled the role of Elk1 in brain processes and its involvement in neurological dysfunctions, including depression and addiction. As a scientific advisor, Jocelyne shares her expertise to guide the Elkedonia team in developing innovative treatments for patients.
Jocelyne Caboche, PhD

President of the Scientific Advisory Board & Co-Founder
Jocelyne has three decades of experience as a Research Director in Neurosciences in the National Center for Scientific Research (CNRS). She is specialized in cellular and molecular processes that govern neuronal plasticity in the brain, with a particular focus on the MAPKinase/ERK signaling pathway, and downstream genetic and epigenetic remodeling of long-term neuronal properties. Her academic team pioneered the discovery of Elk-1 expression and regulation in physiological (learning and memory) and pathophysiological conditions (psychiatric disorders).
Jocelyne was the Director of the Institute of Biology at the University Pierre and Marie Curie (Paris) from 2007 to 2014. She published 140 scientific articles and reviews, in peer-reviewed journals, with more that 11’000 citations and 7 patents.
For her work on Elk1, Jocelyne was awarded the Marcel Dassault / Fondation Fondamental prize for Innovation in Psychiatry in 2023.

Yves Ribeill, PhD
Argobio Studio - Director
Yves Ribeill, PhD
Executive DirectorNC














